New Patients Please Call 731-879-1219

118 E Main Street Henderson, TN 38340 | Current Patients: 731-989-2166 | Fax: 731-989-9685 | Mon-Fri: 7a.m.-7p.m. Sat: 8a.m.-4p.m Sun: Closed

We're a local pharmacy dedicated to your family's health

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Serving The Community Since 1922

Located in Henderson, TN, we've been serving the communities of Henderson and Chester County since 1922. Our pharmacists have 105 years of combined experience and our friendly staff will treat you like family. Here at City Drug Store of Henderson, we are dedicated to providing our customers with services that are customized to meet their needs. City Drug Store of Henderson is your source for all of your pharmaceutical needs, offering conventional prescription filling, compounding, immunizations, med-sync and much more. Whether it’s prescription medications or over the counter products, we are here to answer any and all of your questions. Visit us today to experience the City Drug of Henderson difference.

Special Services



We offer a wide range of compounding services, including veterinary, pain, hospice and hormone replacement therapy.


Free Mobile App

Download our free mobile app to refill prescriptions, set medication reminders and find important news and health info.


Medication Synchronization

Sync your prescriptions with us and pick up ALL of your medications on the same day each month.



We offer a variety of vaccines to keep you healthy. Contact us to learn more about our immunizations.